Journal of General Physiology publishes original work that elucidates basic biological, chemical, or physical mechanisms of broad physiological significance. Apart from scientific quality and rigor, the major criteria for acceptance are originality, mechanistic insight, and interest to a broad readership. Areas in which we particularly welcome submissions include, but are not limited to, membrane protein physiology; protein structure and dynamics; lipid and membrane biophysics; cell mechanics and contractile systems; and intracellular and intercellular signaling. Although the main emphasis is on physiological questions at the molecular and cellular level, we welcome contributions pertaining to any aspect of general physiology. The journal also publishes articles that strive to understand physiological function through innovative model simulations. Methodological articles should provide a substantial technical advance in an area of physiological interest. Articles that are scientifically sound may be rejected if they are felt to lack novelty or breadth of appeal.
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